Molecular BiologyDiabetesPeer-reviewed
Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve mitochondrial architecture and insulin secretion
Eleni Georgiadou, Charanya Muralidharan, Michelle M. Martinez Irizarry…·Guy A. Rutter
This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.
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