Amelia K. Linnemann

The paper identifies an IFN-induced PD-L1 splice variant, PD-L1Δ3, which is retained intracellularly and fails to suppress T cell activation, altering β cell immune communication in type 1 diabetes.

This study shows that Coxsackievirus B3 evades CD8+ T-cell immunity by downregulating HLA Class I and viral peptide presentation, while inducing robust CD4+ T-cell responses and memory formation.

This paper develops a method to efficiently transduce pancreas tissue slices with CaMPARI2 for analyzing calcium responses, finding size-dependent differences in glucose-induced activity between isolated and slice-islets.

This study shows IFN-α induces heterogeneous ROS production in human β-cells, with healthier donors having more ROS-accumulating cells, and identifies enriched immune-related genes in ROS-producing cells.

The paper uses intravital imaging to show glucose-dependent cilia movement in live mouse pancreatic islets.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

This study shows that loss of Robo1 and Robo2 in beta cells disrupts synchronized calcium oscillations in islets of Langerhans in vivo, indicating that islet architecture is essential for this coordination.