Chr̀istophe Magnan

Contributions of the gut microbiota and intestinal gluconeogenesis to metabolic adaptations in a mouse model of anorexia nervosa.

This study investigates how food restriction in a mouse model of anorexia nervosa affects gut microbiota and intestinal gluconeogenesis, revealing their roles in maintaining glucose homeostasis.

The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

This study shows that exendin-4 improves bone strength in ovariectomized mice through a central mechanism, not directly on bone cells.

Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

This study shows that de novo ceramide synthesis in beta-cells is essential for normal insulin production and glucose tolerance, as its inhibition leads to reduced beta-cell mass and impaired glucose regulation.

Western diet feeding since adolescence impairs functional hyperemia probed by functional ultrasound imaging at adulthood and middle age: rescue by a balanced ω-3:ω-6 polyunsaturated fatty acids ratio in the diet

This study shows that a Western diet starting in adolescence impairs functional hyperemia in mice, which can be rescued by balancing omega-3 and omega-6 fatty acids in adulthood.

Mitofusins Mfn1 and Mfn2 are required in the β-cell to preserve mitochondrial architecture and insulin secretion

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.