Author

Constance Kleijwegt

Institut NeuroMyoGèneORCID 0000-0002-9329-0806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Armelle CorpetiD· 2 shared Florent Bressac· 2 shared Patrick LomonteiD· 2 shared Wilhelm BouchereauiD· 2 shared Camille CoheniD· 1 shared Coline SeurreiD· 1 shared Karine MonieriD· 1 shared Laurent SchaefferiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenetics

Armelle CorpetORCID

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2 papers

Recent·Most cited

A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage

Florent Bressac, Tristan Bargain, Constance Kleijwegt, Wilhelm Bouchereau, Lucas Bonnefoy, Karine Monier, Patrick Lomonte, Armelle Corpet

This study shows that p97 and PML nuclear bodies regulate cGAS degradation after DNA damage, affecting the DNA damage response and senescence.

bioRxiv · Oct 24, 2025 · PreprintGenetics

Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

Constance Kleijwegt, Florent Bressac, Coline Seurre, Wilhelm Bouchereau, Camille Cohen, Pascale Texier, Thomas Simonet, Laurent Schaeffer, Patrick Lomonte, Armelle Corpet

The paper identifies SUMO-SIM interactions as essential for HIRA recruitment to PML NBs and shows PML NBs regulate HIRA distribution and H3.3 deposition at ISGs during IFN-I response.

eLife · May 5, 2023Peer-reviewedGenetics