Wilhelm Bouchereau

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway

This study identifies defective muscle stem cell plasticity in dermatomyositis patients, linked to chronic inflammation and disrupted H3.3 chromatin loading, impairing myogenesis.

A p97-PML NBs axis is essential for chromatin-bound cGAS untethering and degradation upon senescence-prone DNA damage

This study shows that p97 and PML nuclear bodies regulate cGAS degradation after DNA damage, affecting the DNA damage response and senescence.

Epigenetic control of myogenic identity of human muscle stem cells in Duchenne Muscular Dystrophy

The paper investigates how epigenetic changes in muscle stem cells from Duchenne Muscular Dystrophy patients lead to loss of myogenic identity and identifies MEF2B as a key mediator.

Interplay between PML NBs and HIRA for H3.3 dynamics following type I interferon stimulus

The paper identifies SUMO-SIM interactions as essential for HIRA recruitment to PML NBs and shows PML NBs regulate HIRA distribution and H3.3 deposition at ISGs during IFN-I response.

Major transcriptomic, epigenetic and metabolic changes underly the pluripotency continuum in rabbit preimplantation embryos

This study maps the transcriptomic, epigenetic, and metabolic changes in rabbit preimplantation embryos, identifying novel markers of naive pluripotency and similarities to human and primate embryos.