Laurent Schaeffer

This study identifies the AMPK2/PHF2 axis as essential for lipid droplet turnover in muscle stem cells during regeneration, showing that PHF2 promotes lipid droplet-mitochondria contact.

This study shows that combining HDAC6 inhibitors with SMN2 splicing modifiers improves muscle function and survival in a SMA mouse model.

The paper shows that human muscle fibroblasts and stem cells stimulate motor neuron growth and viability, with effects enhanced by exercise and mitigated by age.

This study identifies LSD1 as a regulator of Wnt/β-catenin signaling by demethylating β-catenin to prevent its degradation, thereby influencing muscle stem cell self-renewal.

The paper shows that SMN shuttles from Cajal bodies to the nucleolus during DNA repair, aiding in nucleolar structure restoration after genotoxic stress.

The paper identifies SUMO-SIM interactions as essential for HIRA recruitment to PML NBs and shows PML NBs regulate HIRA distribution and H3.3 deposition at ISGs during IFN-I response.