Andreas Papassotiropoulos

Abnormal Tau Protein Influences Intercellular Mitochondrial Transfer Between Astrocytic and Neuronal Cells

This study shows abnormal tau protein increases mitochondrial transfer from astrocytes to neurons via contact-dependent mechanisms, affecting mitochondrial function in tauopathies.

Polygenic susceptibility for multiple sclerosis is associated with working memory in low-performing young adults

This study links polygenic MS risk to working memory performance in low-performing young adults but not to white matter properties.

(-)-Gossypol inhibition of musashi-mediated forgetting improves memory and age-dependent memory decline in Caenorhabditis elegans

This study shows that inhibiting musashi proteins with (-)-gossypol improves memory and reverses age-related memory decline in C. elegans without affecting other behaviors.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Genetic control of variability in subcortical and intracranial volumes

The paper identifies genetic loci associated with variability in brain volumes and thickness, showing they are distinct from loci affecting mean volumes.

Genetics of brain age suggest an overlap with common brain disorders

The paper estimates brain age gaps using MRI and machine learning in individuals with and without brain disorders, finding heritability and genetic overlap with common disorders.

Brain scans from 21297 individuals reveal the genetic architecture of hippocampal subfield volumes

This study identifies 15 genome-wide significant loci associated with hippocampal subfield volumes in 21,297 individuals, revealing distinct genetic determinants for different subfields.