Christopher Edward Brightling

Topology-Based Query Framework for Longitudinal Omics Trajectories

LongOmicsTraj provides a topology-based framework to represent and query longitudinal omics trajectories, identifying corticosteroid response genes with temporal patterns across treatment groups.

Reported estimates of human airway dimensions are inconsistent across studies

The paper evaluates inconsistencies in reported human airway dimension estimates across studies and introduces an open-access database for standardized geometric inputs.

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry

This study identifies a genetic association between thromboembolism risk and long COVID in individuals of European ancestry, suggesting thromboembolism as a potential contributor to long COVID pathogenesis.

Bacteriophage diversity declines with COPD severity in the respiratory microbiome

The paper examines bacteriophage diversity in COPD patients and finds it declines with disease severity, showing disrupted viral-bacterial relationships in those with frequent exacerbations.