Martha R. J. Clokie

Isolation and characterization of novel Klebsiella phages from Benin and their antibiofilm activities on multidrug resistant and hypervirulent strains of Klebsiella pneumoniae

The paper isolates and characterizes three novel Klebsiella phages from Benin that inhibit biofilm formation in multidrug-resistant and hypervirulent K. pneumoniae strains.

Isolation and characterisation of Lytic Jumbo Klebsiella phage BMPCR_005026

The paper isolates and characterizes a new jumbo Klebsiella phage, BMCPR_005026, identifying it as a new species within the Alcyoneusvirus genus with limited host range.

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli

This study evaluates how the urinary microenvironment and fluid flow affect antibiotic and phage therapy against UPEC, showing that physiological conditions reduce treatment efficacy.

Large scale antibiotic-phage synergy studies reveal key combinations for urinary tract infection and urosepsis treatments

This study screens phage-antibiotic combinations in clinical isolates to identify synergistic interactions for treating resistant infections.

Characterisation of novel bacteriophages against the cattle pathogen Moraxella bovis

The paper isolates and characterizes four novel bacteriophages against Moraxella bovis, finding high genomic similarity among three and distinct properties in MB43.

Rolling out plaque-2-sequence: a single plaque sequencing approach enabling rapid, low-cost sequencing of phages directly from plaques

This paper introduces plaque-2-sequence, a low-cost, high-throughput method for sequencing phage genomes directly from plaques, enabling rapid and scalable genomic analysis of phages.

Bacteriophage pharmacodynamics studied in an in vitro pharmacokinetic model of infection

This study uses in vitro models to evaluate the antibacterial effects and pharmacodynamics of a bacteriophage cocktail against E. coli strains, showing strain-specific responses and phage titre changes.

Bacteriophage diversity declines with COPD severity in the respiratory microbiome

The paper examines bacteriophage diversity in COPD patients and finds it declines with disease severity, showing disrupted viral-bacterial relationships in those with frequent exacerbations.

Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential

The paper identifies thousands of lytic phage genomes within bacterial assemblies, expanding known phage diversity and suggesting clinical isolates may contain therapeutic phage candidates.

In-vivo Efficacy of a Phage Cocktail Therapy that Targets ESBL-producing Klebsiella species that cause Urinary Tract Infections

This study evaluates a phage cocktail's efficacy against ESBL-producing Klebsiella UTIs in mice, showing reduced bacterial burden and inflammation.

Development of antibacterial drug plus bacteriophage combination assays

This study evaluates how phages interact with antibacterials using standardized assays and finds that phages can increase or decrease antibiotic MICs depending on the strain and combination.

The relationship between microbial community succession, decay, and anatomical character loss in non-biomineralised animals

This study investigates the role of microbial communities in decay and anatomical character loss, finding that endogenous bacteria dominate and that microbial succession does not control anatomical decay sequences.

The structurome of a Clostridium difficile phage and the remarkable accurate prediction of its novel phage receptor-binding protein

The paper identifies and characterizes a novel receptor-binding protein from a Clostridium difficile phage, revealing its structure and function, and demonstrates the accuracy of AlphaFold2 predictions for structurome analysis.

Rapid discovery of novel prophages using biological feature engineering and machine learning

The paper introduces a machine learning method for detecting prophages in bacterial genomes, finding more phages than existing tools while being faster.

Oscillating bacterial expression states generate herd immunity to viral infection

The paper shows bacteria use hypermutable loci to generate herd immunity against phage infection by creating resistant sub-populations that block phage spread.