Jörn Dengjel

This study identifies VRK-1 as a regulator of chromatin-nuclear lamina interactions in C. elegans, showing its role in stress-induced chromatin reorganization and survival.

The paper describes a protocol for preparing tissue samples for proteome and phosphoproteome analysis using mass spectrometry, including steps for tissue disruption, lipid depletion, and phosphopeptide enrichment.

This study identifies a lymphoid tissue chemokine checkpoint that regulates CD8+ T cell release from dendritic cells, preventing loss of effector function.

This study shows autophagy contributes to MHC class II presentation of RA-related peptides in HLA-DRB1*04:01 alleles, with 30% of peptides differing between autophagy sufficient and deficient cells.

This study identifies an FGF7-FGFR2-KLF4 feedback loop that maintains anti-inflammatory signaling in epithelial cells, offering potential therapeutic strategies for inflammatory diseases.

The paper identifies Acl1 and Bcl1 as dedicated chaperones for Rpl1 by using proximity labeling and structural analysis in yeast.

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

The paper identifies AIFM1's interaction with AK2A and shows how this stabilizes AK2A and enhances NADH oxidoreductase activity, highlighting AIFM1's role in energy metabolism.

The paper identifies two mitophagy peaks during retinal development, one PINK1-independent and one PINK1-dependent, linked to oxidative stress and RGC differentiation.

This study identifies CMK-1 and TAX-6/CnA as antagonistic regulators of thermo-nociceptive adaptation in C. elegans, acting in distinct neurons to modulate noxious heat avoidance behaviors.

The paper identifies S210 phosphorylation of Lamin B1 by ULK1 and Aurora A/PLK1 as critical for spindle function during mitosis.

The paper introduces a method to quantify SnRK1.1 spatiotemporal localization using fluorescence confocal imaging and validates it with DCMU treatment and software comparison.

The paper investigates dermokine's role in keratinocyte adhesion through multi-omics analysis, showing that dermokine loss increases p120 phosphorylation and reduces cell-cell adhesion.

This study uses targeted proteomics to analyze protein degradation patterns during autophagy, revealing differential responses of selective autophagy receptors to various stimuli.

This study shows that autophagy-dependent loss of ribosomal proteins during starvation in C. elegans balances survival and recovery speed by affecting growth resumption.

The paper measures collagen content in mice tissues and whole bodies, finding collagen constitutes 12% in females and 17% in males of total protein.

This study identifies CDK5 as a kinase that regulates the mammalian circadian clock by phosphorylating PER2, facilitating its nuclear entry and maintaining circadian period.

This study examines how deep brain stimulation of the basal forebrain affects extracellular vesicle-related proteins in rat brain regions.