Anna A. Kapitonova

This paper uses integrated solid and solution NMR to study dynamics and ligand binding in a 134 kDa enzyme, revealing structural flexibility and substrate interactions.

The paper compares aromatic ring flip kinetics in GB1 protein across crystals, IgG complexes, and solution, showing reduced flipping in crystals and revealing how crystal environments restrain motion.

The paper identifies a dynamic displacement mechanism in mitochondrial protein import, showing that a flexible segment of Tom22 facilitates precursor protein release.

This study identifies four phosphorylation sites in NPM1 that enable 14-3-3 protein binding, revealing how phosphorylation regulates NPM1's nucleocytoplasmic shuttling and structural dynamics.