Jialu Xu

The paper determines the in situ structure of prefusion hemagglutinin on influenza virions and shows how HA trimers form cooperative assemblies that coordinate membrane fusion.

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

This study uses cryo-ET to capture complete SARS-CoV-2 fusion intermediates, revealing structural changes and the inhibitory effect of the WS6 S2 antibody.

This paper identifies a mutation, G225R, that restores capsid formation and infectivity to HIV-1 mutants deficient in IP6 packaging by stabilizing the capsid structure in low-IP6 conditions.

DeChat corrects errors in Nanopore R10 sequencing reads with high accuracy, preserving repeats and haplotypes, and improves genome assembly.

HERO improves error correction in long reads by combining de Bruijn and overlap graphs, reducing indel and mismatch errors by 65% and 20% respectively.

This study identifies TRAP as essential for insulin biogenesis, showing it facilitates preproinsulin translocation and affects downstream processing and secretion.