Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16
Ying Ru, Meng Ma, Xianxiao Zhou, Divya Kriti, Ninette Cohen, Sunita L. D’Souza, Christoph Schaniel, Susan M. Motch Perrine, Sharon Kuo, Oksana Pichurin, Dalila Pinto, Genevieve Housman, Greg Holmes, Eric E. Schadt, Harm van Bakel, , Meng Wu
The paper identifies KLF16 as an inhibitory regulator of osteogenic differentiation through transcriptomic analysis of human iPSC-derived cells and in vivo validation.
bioRxiv · Feb 11, 2024 · PreprintDevelopmental Biology