Greg Holmes

This study investigates the role of Fibronectin 1 in suture patency and its dysregulation in craniosynostosis models in mice, identifying FN1 as a key regulator of calvarial growth and cell differentiation.

This study shows that graded Fibronectin (FN1) cues guide calvarial osteoblast migration and suture patency, with disruptions in FN1 or related pathways causing craniosynostosis in mice.

The paper identifies KLF16 as an inhibitory regulator of osteogenic differentiation through transcriptomic analysis of human iPSC-derived cells and in vivo validation.

The paper uses single-cell RNA-seq to identify Hhip's role in murine coronal suture development, showing its necessity for maintaining suture mesenchyme and osteogenic fronts.