Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity
Leslie A. Kirby, Jing Jin, Jaime Gonzalez Cardona, Matthew D. Smith, Kyle A. Martin, Jingya Wang, Hayley J. Strasburger, Leyla Herbst, Maya Alexis, Jodi L. Karnell, Todd S. Davidson, Ranjan Dutta, Joan M. Goverman, Dwight E. Bergles, Peter A. Calabresi
This study shows OPCs can cross-present antigen and mediate cytotoxicity in MS, suggesting they are co-opted by the immune system.
bioRxiv · Nov 4, 2018 · PreprintNeuroscience