NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
GSAP modulates γ-secretase specificity by inducing conformational change in PS1
Eitan Wong, George Paul Liao, Jerry C. Chang…·Paul Greengard
This study shows GSAP reduces Aβ production without affecting Notch1 cleavage, suggesting it modulates γ-secretase specificity through conformational changes in PS1.
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