Jerry C. Chang

Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression

This study identifies astrocyte-derived extracellular matrix proteins, particularly SPARC, as regulators of synapse remodeling in stress-induced depression.

GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer's disease

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

GSAP Regulates Amyloid Beta Production through Modulation of Amyloid Precursor Protein Trafficking

This study shows GSAP regulates amyloid beta production by modulating APP trafficking, specifically by affecting the immobile vesicle pool associated with amyloidogenic processing.

GSAP modulates γ-secretase specificity by inducing conformational change in PS1

This study shows GSAP reduces Aβ production without affecting Notch1 cleavage, suggesting it modulates γ-secretase specificity through conformational changes in PS1.