Author

Eitan Wong

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-2713-4549Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Jerry C. ChangiD· 3 shared Paul GreengardiD· 3 shared Peng XuiD· 3 shared Yue‐Ming LiiD· 3 shared Marc FlajoletiD· 2 shared Angus Clark NairniD· 1 shared George Paul LiaoiD· 1 shared Huaxi XuiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Jerry C. ChangORCID

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3 papers

Recent·Most cited

NeuroscienceThe Journal of Experimental MedicinePeer-reviewedMay 27, 2021

GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer's disease

Peng Xu, Jerry C. Chang, Xiaopu Zhou…·Paul Greengard

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

33 citations

mousebulk RNA-seq

NeurosciencebioRxivPreprintNov 12, 2020

GSAP Regulates Amyloid Beta Production through Modulation of Amyloid Precursor Protein Trafficking

Jerry C. Chang, Peng Xu, Eitan Wong…·Paul Greengard

This study shows GSAP regulates amyloid beta production by modulating APP trafficking, specifically by affecting the immobile vesicle pool associated with amyloidogenic processing.

3 citations

humanimaging

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedMar 8, 2019

GSAP modulates γ-secretase specificity by inducing conformational change in PS1

Eitan Wong, George Paul Liao, Jerry C. Chang…·Paul Greengard

This study shows GSAP reduces Aβ production without affecting Notch1 cleavage, suggesting it modulates γ-secretase specificity through conformational changes in PS1.

63 citationstop 2%

experimental assay