Peng Xu

Focal dopaminergic axon swellings in the dorsolateral striatum of Synj1 R259Q mutant mice are clusters of DAT-rich, onion-like plasma membrane invaginations, and the same region shows reduced evoked dopamine release.

This study investigates how noradrenergic signaling changes with behavioral states and its impact on cortical network activity and connectivity.

This study shows lysine lactylation at stress-response gene TSSs is enriched under glucose starvation in canine hemangiosarcoma and correlates with transcriptional activation.

This study shows that double knockout of Vps13a and Vps13c in mice causes embryonic lethality due to impaired hematopoiesis and innate immune activation.

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

This study identifies interactions that mediate BLTP2 localization at ER-PM contacts and shows its role in controlling plasma membrane dynamics through lipid transport.

This study investigates how a mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons, revealing impaired protein clearance and altered Ca2+ channel distribution.

This study identifies GSAP's role in Alzheimer's disease by showing it regulates mitochondrial function through the MAM and lipid homeostasis, with a SNP linked to increased AD risk.

This study shows GSAP regulates amyloid beta production by modulating APP trafficking, specifically by affecting the immobile vesicle pool associated with amyloidogenic processing.

This study shows GSAP reduces Aβ production without affecting Notch1 cleavage, suggesting it modulates γ-secretase specificity through conformational changes in PS1.