Author

Sebastian Klinge

Rockefeller UniversityORCID 0000-0002-9373-4737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Alain FischeriD· 1 shared Alain Lefèvre‐UtileiD· 1 shared Alexander Antipenko· 1 shared Alexandre BolzeiD· 1 shared Andrej KošmrljiD· 1 shared Andrew John PollardiD· 1 shared Angela L. HewlettiD· 1 shared Anita DonliciD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Alain FischerORCID

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 22, 2026

Mechanism for the initiation of co-transcriptional pre-60S assembly

Rafał Piwowarczyk, Sebastian Klinge

This study identifies the earliest co-transcriptional assembly intermediates of the eukaryotic 60S subunit and reveals the molecular logic of an assembly checkpoint.

DOI 10.64898/2026.05.22.727207

experimental assaychromatin & epigenetic regulation

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BiochemistryNaturePeer-reviewedOct 29, 2025

Helicase-mediated mechanism of SSU processome maturation and disassembly

Olga Buzovetsky, Sebastian Klinge

This study identifies helicase-mediated mechanisms for SSU processome maturation and disassembly using structural and genetic data.

8 citations

structural biologyexperimental assay

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Cell BiologyNaturePeer-reviewedJul 2, 2025

Mapping and engineering RNA-controlled architecture of the multiphase nucleolus

Sofia A. Quinodoz, Lifei Jiang, Aya A. Abu-Alfa…·Clifford P. Brangwynne

The paper maps rRNA processing dynamics in the nucleolus and shows how rRNA processing affects nucleolar phase organization and structure.

73 citationstop 1%

humanbulk RNA-seq

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedAug 2, 2018

Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons

Alexandre Bolze, Bertrand Boisson, Barbara Bosch…·Jean‐Laurent Casanova

The paper reports new RPSA mutations causing isolated congenital asplenia, including 5-UTR mutations and incomplete penetrance in some cases.

44 citations

human

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