Aya A. Abu-Alfa

The paper uses single-cell spatial transcriptomics to map transcriptional responses to inherited retinal degeneration across the retinal axis, revealing both broad and focal spatial organization of disease-related gene expression.

This study identifies late-stage processing bottlenecks in ribosome biogenesis caused by oncogene activation, which impair ribosome production and limit tumor growth.

The paper shows that molecularly aged ribosomes alter translational dynamics by impairing elongation and increasing ribosome collisions during organismal aging.

The paper maps rRNA processing dynamics in the nucleolus and shows how rRNA processing affects nucleolar phase organization and structure.