Single-cell transitional dynamics unravel stimulus- and cell type-dependent signaling outputs of distinct p53 regulatory feedback motifs
Jun Xie, Lichun Zhang, Yanting Zhu, Xiao Liang, Jue Shi
The paper uses single-cell imaging and mathematical modeling to analyze p53 pathway dynamics in response to chemotherapeutics, identifying novel feedback motifs and their role in context-specific signaling responses.
BMC Biology · Apr 11, 2022Peer-reviewedSystems Biology