Author

Dong Sun Lee

Korea Advanced Institute of Science and TechnologyORCID 0000-0002-9385-6136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Ho Min KimiD· 3 shared Jinsook AhniD· 2 shared Ryeongeun ChoiD· 2 shared Abigail E. BurtneriD· 1 shared Adri Tran-Pearson· 1 shared Brian CoventryiD· 1 shared Cameron CriswelliD· 1 shared Chloe S. AdamsiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

Ho Min KimORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ProteinSketch translates spatial intuition into protein design with bimanual interaction in VR

Donghyeok Ma, Junyup Lee, H. C. Lee, Sang-Hyun Lee, Yeong Gyeong Oh, Ye-eun Kim, Taegyu Jin, Siripon Sutthiwanna, Seung-Jun Lee, Woosung Jeon, Dong Sun Lee, Jinsook Ahn, Ryeongeun Cho, H C Park, Seongin Jeong, , Ho Min Kim

ProteinSketch enables interactive protein design in VR by translating spatial intuition into constraints for AI-driven protein structure generation.

bioRxiv · Jul 20, 2026 · PreprintBioengineering

De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics

Jinsook Ahn, Ryeongeun Cho, S. B. Kim, Dong Sun Lee, Ho Min Kim

This paper designs high-affinity GDF15 binders using AI-driven methods for cancer cachexia diagnostics and therapeutics, showing potent neutralization and biosensing capabilities.

Experimental & Molecular Medicine · May 8, 2026Peer-reviewedBioengineering

De novo design of protein minibinder agonists of TLR3

Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

This study designs protein minibinders that act as agonists for TLR3, showing nanomolar binding and biological activity in cell lines.

Nature Communications · Jan 31, 2025Peer-reviewedBiochemistry