Tal Kafri

PETScan performs genome-wide association analysis of RNA-Seq and ATAC-Seq data using negative binomial models and score tests, achieving faster computation than Wald tests while identifying similar significant gene-peak pairs.

This study shows that increasing Cathepsin B in skeletal muscle of Alzheimer's mice improves memory and neurogenesis without affecting plaque pathology.

MITScan performs genome-wide association analysis between microbiome and host transcriptome using zero-inflated negative binomial models, achieving computational efficiency with score tests and permutation methods.

The paper identifies a glutamatergic signaling network involving GRM5, GCPII, and GRM3 as a genetic mediator of daily sleep patterns through QTL mapping in mice.

The paper characterizes hepatic lentiviral vector transduction in mice, finding strain-specific variations and QTLs linked to transduction efficiency and kinetics, suggesting the need for personalized gene therapy protocols.

The paper updates the MiniMUGA genotyping array's bioinformatic pipeline to enhance genetic QC in laboratory mice by improving marker annotation, consensus genotypes, and report usability.

The paper introduces MiniMUGA, a genotyping array for mouse genetic QC, showing it effectively discriminates strains, detects genetic constructs, and identifies sex chromosome abnormalities.