Graham H. Diering

This study shows chronic diphenhydramine treatment fragments NREM2 sleep and degrades sleep quality in both 5XFAD Alzheimer's mice and wild-type mice.

The paper characterizes organelle differences and stress responses between neurons and astrocytes using live-cell imaging and quantitative analysis.

The paper identifies a glutamatergic signaling network involving GRM5, GCPII, and GRM3 as a genetic mediator of daily sleep patterns through QTL mapping in mice.

The paper characterizes hepatic lentiviral vector transduction in mice, finding strain-specific variations and QTLs linked to transduction efficiency and kinetics, suggesting the need for personalized gene therapy protocols.

This study examines the effects of sleep deprivation on synaptic vulnerability across developmental stages in mice, finding heightened sensitivity in juveniles and links to ASD risk.

This study shows that sleep disruption accelerates cognitive decline in male P301S Tau mice but not females, without directly causing synaptic Tau pathology.

This study shows TRIM9 localizes to dendritic spines and regulates actin dynamics and synaptic responses to netrin-1 during synaptogenesis.

This study shows that chronic hyperexcitation in cultured neurons triggers homeostatic downscaling and enhances endocannabinoid signaling through coordinated changes in FAAH, anandamide, and CB1.

This study examines how different morphine withdrawal paradigms affect sleep behavior in male and female mice, finding sex-specific differences and highlighting the 3-day precipitated withdrawal model as most impactful.

This study identifies tSNARE1 as a schizophrenia risk gene that regulates endolysosomal trafficking in cortical neurons through its isoforms' effects on endosomal cargo movement.