Jona Kayser

Quantitative assessment of mesoscale cellular order and organization in the mouse hippocampus

The paper quantifies mesoscale cellular organization in the mouse hippocampus using a new software tool, revealing cell-type-specific nuclear shape variations and positionally ordered but orientationally disordered dense regions.

Crowding governs resistance confinement and guides the improvement of adaptive therapy in a 2D melanoma model system

This study shows how mechanical crowding in 2D melanoma models influences resistance expansion and therapy failure, guiding adaptive therapy improvement through physical and computational models.

Reinforcement Failing guides the discovery of emergent spatial dynamics in adaptive tumor therapy

This paper introduces Reinforcement Failing, an AI framework that identifies emergent spatial dynamics in adaptive tumor therapy by refining training environments.

Spatial resource dynamics control resistance escape

This study shows how intermittent treatment pulses reshape resource landscapes and spatial growth zones, enabling resistant mutants to escape confinement and drive therapy failure.

High-Throughput Mechanomic Screening Reveals Novel Regulators of Single-Cell Mechanics

This study uses high-throughput mechanomic screening to identify 80 genes regulating single-cell mechanics, including novel regulators, using RT-FDC technology.