Buzz Baum

The paper identifies candidate eukaryote homologs of Asgard archaea by analyzing structural clusters, revealing shared expansions of solenoid proteins.

This study shows how two Rickettsiales bacteria, Orientia tsutsugamushi and Rickettsia rhipicephali, distribute during host cell division, with O. tsutsugamushi using microtubules for symmetric inheritance and R. rhipicephali inhibiting mitosis.

This study identifies TFB2, a TFIIB paralog, as a key regulator of cyclic transcription in Sulfolobus acidocaldarius, linking it to cell cycle progression without CDKs.

This study reveals that Ignicoccus hospitalis uses a contractile CdvA-ESCRT-III ring to constrict its inner membrane, leading to multi-cytoplasmic clusters and subsequent release of progeny cells through outer membrane bursting.

The paper shows that PAR-3 proteins form stable clusters during anoxia in C. elegens embryos, preserving polarity information for rapid reactivation after metabolic arrest.

The paper develops a tryptophan auxotrophy-based selection system in Sulfolobus acidocaldarius to study S-layer assembly during cytokinesis, revealing spatial localization of SlaA and SlaB at the division bridge.

This paper identifies minimal monomer design principles for treadmilling filaments using physical modeling and in silico evolution, showing how conformational changes enable directional growth and fragmentation-free disassembly.

This study shows that archaeal ESCRT-III homologue CdvB1 binds phosphoinositides and helps polarize the cytokinetic membrane in Sulfolobus acidocaldarius.

The paper shows that 3D epithelial cell geometry and topology influence Notch-Delta signalling range, affecting cell fate patterning in Drosophila wing margins.

The paper develops a thermostable green fluorescent protein, Matcha, for live imaging in hyperthermophiles and uses it to study division ring dynamics in Sulfolobus.

The paper presents structural studies of the archaeal CdvAB cell division machinery, showing CdvA forms helical filaments and CdvB adopts ESCRT-III-like folds, revealing membrane engagement mechanisms.

This study identifies an ancient membrane fission mechanism in Asgard archaea, showing ESCRT-III's role in cell compartmentalization predates eukaryogenesis.

This paper identifies an Asgard archaeon with an endomembrane system that changes with cell state, challenging previous views on eukaryogenesis.

This study investigates how DNA segregation and cell division are coordinated in archaea, identifying regulatory checkpoints and proteins involved in ensuring accurate genome distribution.

This study uses high-throughput mechanomic screening to identify 80 genes regulating single-cell mechanics, including novel regulators, using RT-FDC technology.

This study identifies the mechanism of cell cycle-dependent proteasome-mediated CdvB degradation in Sulfolobus acidocaldarius, revealing a role for a novel transcription factor and proteasome-activating nucleotidase.

The paper identifies evolutionarily conserved principles of ESCRT-III-mediated membrane remodeling using an Asgard archaeal two-subunit system, showing homology to eukaryotic ESCRT-IIIB and IIIA.

The paper shows that the S-layer in Sulfolobus acidocaldarius aids cell division by reshaping the cytokinetic furrow through its flexible self-assembly, enhancing ESCRT-III-dependent division under mechanical stress.

This study uses temperature-sensitive mutants in Sulfolobus acidocaldarius to identify a ribosomal mutation that blocks translation and prevents cell division, linking translation to cell cycle control.

The paper uses a computational model to study how archaeal membrane lipids balance stability and flexibility, finding that adding bilayer lipids to bolalipid membranes achieves both.

NanoJ provides a high-performance open-source toolbox for super-resolution microscopy, offering tools for data alignment, image reconstruction, quality assessment, structural modeling, and sample control.

The paper shows actomyosin dynamics control stress relaxation in epithelial monolayers, enabling active changes in resting length during mechanical deformation.

The paper shows that actomyosin contractility enhances Notch-mediated signaling and patterning in fly dorsal thorax development through basal protrusions.