Tomohisa Toda

Quantitative assessment of mesoscale cellular order and organization in the mouse hippocampus

The paper quantifies mesoscale cellular organization in the mouse hippocampus using a new software tool, revealing cell-type-specific nuclear shape variations and positionally ordered but orientationally disordered dense regions.

Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.