Author

Wayne I. Lencer

Boston Children's HospitalORCID 0000-0001-7346-2730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Jay R. ThiagarajahiD· 2 shared Krishnan RaghunathaniD· 2 shared Stefanie S. SchmiederiD· 2 shared Aaron J. MauraisiD· 1 shared Aleixo M. MuiseiD· 1 shared Ana Paula SchaaniD· 1 shared Ana Prado· 1 shared Anne K. KenworthyiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

Jay R. ThiagarajahORCID

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4 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 14, 2026

Blautia wexlerae Transforms Dietary Fatty Acids to Activate Enteroendocrine Signaling and Improve Metabolic Health in Mice and Humans

Yanjia Jason Zhang, Marian Tanofsky‐Kraff, Mildred-Maria Reyes…·Eric J. Alm

This study identifies Blautia wexlerae's role in converting dietary fats into bioactive metabolites that enhance gut hormone secretion and improve metabolic health in mice and humans.

DOI 10.64898/2026.03.13.709143

humanmouse

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Cell BiologybioRxivPreprintOct 1, 2025

Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids

Stefanie S. Schmieder, Joanna Podkalicka, Christine Viaris de Lesegno…·Wayne I. Lencer

The paper shows that palmitoylated caveolin-1 facilitates endosome sorting of complex sphingolipids to the plasma membrane, independent of caveolae.

DOI 10.1101/2025.10.01.679304

experimental assaycell signaling & trafficking

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Cell BiologybioRxivPreprintMay 9, 2025

Trans-kingdom coupling of redox signaling to environmental cell stress responses through multiphase partitioning.

Elsy M. Ngwa, Xi Chen, Stefanie S. Schmieder…·Jay R. Thiagarajah

This paper identifies RACK1 as a redox-regulated hub that coordinates cellular stress responses through condensate-based microdomains, linking environmental stress to immune signaling and translational control.

DOI 10.1101/2025.05.09.653213

humanbacteria (other)

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Cell BiologybioRxivPreprintMar 22, 2025

TTC7A organizes glandular lumen formation in the intestine through a Class II phosphatidylinositol 3-kinase

Katlynn Bugda Gwilt, Dhanushan Wijayaratna, Geordie Emberling…·Jay R. Thiagarajah

This study identifies TTC7A's role in intestinal lumen formation by chaperoning PIK3C2A to generate PI(3,4)P2, with loss-of-function variants causing multiple lumens and rescue possible via exogenous PI(3,4)P2.

DOI 10.1101/2025.03.22.644724

humanexperimental assay

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