Author

Hugh R. Higinbotham

Massachusetts Institute of TechnologyORCID 0000-0002-9418-7958Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Barbara ImperialiiD· 2 shared Christine A. ArbouriD· 2 shared Greg J. DodgeiD· 1 shared Karen N. AlleniD· 1 shared Roxanne P. SiudaiD· 1 shared Soumi GhoshiD· 1 shared Theo DurandiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Barbara ImperialiORCID

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2 papers

Recent·Most cited

BiochemistryProtein SciencePeer-reviewedOct 23, 2025

Correlating membrane-protein dynamics with function: Integrating bioinformatics, molecular dynamics, and single-molecule FRET

Hugh R. Higinbotham, Christine A. Arbour, Barbara Imperiali

The paper integrates bioinformatics, molecular dynamics, and single-molecule FRET to study ligand-dependent conformational dynamics of membrane proteins.

2 citations

fluorescence / live-cell microscopymechanistic / dynamical model

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedNov 27, 2024

Proteome-Wide Bioinformatic Annotation and Functional Validation of the Monotopic Phosphoglycosyl Transferase Superfamily

Theo Durand, Greg J. Dodge, Roxanne P. Siuda…·Barbara Imperiali

The paper identifies and validates substrate specificity of bacterial monotopic phosphoglycosyl transferases using bioinformatics and in vitro assays, supporting inhibitor discovery for antibiotic development.

5 citations

bacteria (other)proteomics

𝕏 PostBluesky