Omer Karin

This study identifies five classes of endocrine circuits in humans, revealing shared structural and regulatory principles across 43 hormone systems.

The paper develops a mechanistic framework showing how cell cycle criticality enables robust population control by balancing self-renewal and differentiation through sensitivity to mitogenic signals.

EnhancerNet models enhancer selection in regulatory networks to simulate cell type acquisition dynamics through reprogramming or differentiation.

The paper shows that transgenerational gene silencing in C. elegans is maintained by a self-tuning mechanism based on resource competition, leading to long-term memory-like persistence.

The paper measures damage dynamics in individual E. coli cells under carbon starvation and finds that stochastic noise amplification, not initial conditions, drives lifespan variation, with increasing determinism over time.

The paper maps the dopamine circuit to bacterial chemotaxis, showing it functions as a reward-taxis system using fold-change detection to explain the matching law.

The paper proposes a mathematical model of opponent processes in alcohol addiction, linking changes in HPA gland mass to {beta}-endorphin secretion and addiction vulnerability.

The paper analyzes health records to show seasonal patterns in human hormones, finding that effector hormones peak in winter-spring while upstream pituitary hormones peak in summer, suggesting a circannual clock mechanism.

The paper combines theory and experiments in mice to show that senescent cells have a rapid turnover that saturates with age, leading to persistent differences in cell accumulation and explaining demographic mortality laws.

The paper uses dynamic proteomics to study HSV1 infection in individual cells, finding preexisting cell-state differences influence infection outcomes.

The paper clarifies the relationship between dynamical compensation and parameter identifiability by defining DC in terms of parameter identifiability across different system states and measurements.