Yihong Chen

This study benchmarks deep learning models' ability to predict mutation-induced fold switching in proteins using an NMR-characterized dataset of fold-switching mutants.

This paper shows how substrate specificity in a designed RAS-targeting protease is linked to active site and distal motions, revealing mechanisms for enhanced specificity.

This study identifies the RING-H2 domain of Arabidopsis RMR as an E3 ligase required for post-Golgi trafficking of RMR receptors.

This study reveals the conformational dynamics of Paxillin's N-domain interacting with FAK's FAT domain, showing a multi-state complex with functional implications.