Author

Yanan He

Institute for Bioscience and Biotechnology ResearchORCID 0000-0002-0756-4306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:protein sequence· 1

Frequent Co-Authors

John P. OrbaniD· 3 shared Yihong CheniD· 2 shared Alexander GrishaeviD· 1 shared Angela WuiD· 1 shared Atish Ranjan MohantyiD· 1 shared Betty ChuiD· 1 shared Eric A. TothiD· 1 shared Holly R. Hemesath· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

John P. OrbanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A Conserved Flexible N-Terminal Domain Tunes the Calcium Sensitivity of Sorcin by Stabilizing Its Active Conformation

Qiushi Ye, Angela Wu, Kathleen Joyce Carillo, Ibrahim Damilare Boyenle, Holly R. Hemesath, Yanan He, Nicolas Delaeter, Jaekyun Jeon, John P. Orban, Lei Zhang, Yanxin Liu

This study identifies the flexible N-terminal domain of Sorcin as a critical regulator that enhances Ca2+ responsiveness by stabilizing its active conformation through dynamic contacts.

bioRxiv · Aug 4, 2026 · PreprintBiophysics

Substrate specificity in a designed RAS-targeting protease is coupled to active site and distal motions

Betty Chu, Yanan He, Yihong Chen, Eric A. Toth, John P. Orban

This paper shows how substrate specificity in a designed RAS-targeting protease is linked to active site and distal motions, revealing mechanisms for enhanced specificity.

bioRxiv · Jan 15, 2026 · PreprintBiochemistry

Conformational dynamics of Paxillin and its multi-modal interaction with the Focal Adhesion Targeting Domain

S. Bhattacharya, Yanan He, Yihong Chen, Atish Ranjan Mohanty, Alexander Grishaev, Prakash Kulkarni, Ravi Salgia, John P. Orban

This study reveals the conformational dynamics of Paxillin's N-domain interacting with FAK's FAT domain, showing a multi-state complex with functional implications.

Science Advances · Jun 18, 2025Peer-reviewedBiophysics