Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Brian D. Cosgrove, Lexi R. Bounds, Carson Key Taylor, Alan L Su, Anthony J. Rizzo, Alejandro Barrera, Tongyu Sun, Alexias Safi, Lingyun Song, Thomas J. Whitlow, Aleksandra Tata, Nahid Iglesias, Yarui Diao, Purushothama Rao Tata, Brenton D. Hoffman, , Charles A. Gersbach
The paper identifies mechanoenhancers that regulate transcription in response to matrix stiffness and shows their potential for reprogramming cellular responses to mechanical cues.
Science · Sep 25, 2025Peer-reviewedGenomics