Brenton D. Hoffman

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

This study shows that physical continuity between biomaterials and the extracellular matrix reduces fibroblast activation and fibrosis by inhibiting NF-κB signaling.

The paper identifies mechanoenhancers that regulate transcription in response to matrix stiffness and shows their potential for reprogramming cellular responses to mechanical cues.

The paper shows that fibulin-1 is delivered on-demand to the basement membrane during stretching in C. elegans, maintaining its structure and enabling repeated organ expansion.

This study shows that vinculin Y822 phosphorylation regulates cardiomyocyte adhesion dynamics and adherens junction maturation, with loss of function leading to cardiac dysfunction later in life.

This paper detects fluorescent protein mechanical switching in living cells using FRET-based biosensors and shows it is reversible and influenced by cellular forces.