Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cells
Vakil Takhaveev, Nikolai J. L. Püllen, Navnit K. Singh, Lucie Lefevre, Emilie A. Aghajani, Sabrina M. Huber, Stefan Schauer, Hailey L. Gahlon, Anna R. Poetsch, Shana J. Sturla
The paper improves click-code-seq for mapping DNA oxidation and depurination in human genomes, revealing strand bias in oxidized guanines and apurinic sites.
Nature Chemical Biology · Oct 31, 2025Peer-reviewedGenomics