Orlando D. Schärer

The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair

This study investigates the role of XPG interactions with TFIIH subunits p62 and XPD in nucleotide excision repair, showing their importance for catalytic activity and incision initiation.

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms

The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.

STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

This study identifies STK19 as a factor facilitating the transition from initial TCR complex assembly to downstream repair steps by enabling RNAPII clearance.

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

MSH2-MSH3 promotes DNA end resection during HR and blocks TMEJ through interaction with SMARCAD1 and EXO1

This study identifies MSH2-MSH3's role in promoting DNA end resection during HR and inhibiting TMEJ by interacting with SMARCAD1 and EXO1.