Shana J. Sturla

This paper develops a fermentation workflow to assess gut microbiome biotransformation capacity using chemical probes and metabolomics, showing that experimental conditions and donor variability influence transformation profiles.

This study investigates bidirectional interactions between fluorinated chemicals and gut microbiota using ex vivo, in vitro, and in silico methods, revealing microbial biotransformation and potential detoxification effects.

This study shows UVA radiation causes mitochondrial DNA common deletion via ROS, while UVB causes it through a ROS-independent mechanism, identifying mtDNA CD as a biomarker for UVA-induced damage.

The paper improves click-code-seq for mapping DNA oxidation and depurination in human genomes, revealing strand bias in oxidized guanines and apurinic sites.

The paper predicts internal exposures of bisphenol analogs using physiologically based kinetic models with multimodal parameterization, showing variability in concentrations by age, sex, and organ.

The paper profiles chemical activities in rat gut microbiota to assess changes in biotransformation capacity after exposure to drugs and dietary compounds, finding significant alterations with certain antibiotics.

The paper develops a method to map 5'-aldehyde termini in DNA at single-nucleotide resolution, revealing a preference for adenine bases and linking these lesions to genomic features and chromatin accessibility.

The paper develops a physiologically based kinetic model to predict in vivo concentrations of hop phytoestrogens in human blood and tissues under dietary exposure.

This study identifies catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis using CRISPR screening and TLS analysis.