Weaverly Colleen Lee

High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses

This study uses high-throughput spheroid profiling to show BMP2 and BMP4 rewire glioma cell death responses by suppressing standard therapies and priming for lipid-dependent necrosis.

NMJ-Analyser: high-throughput morphological screening of neuromuscular junctions identifies subtle changes in mouse neuromuscular disease models

NMJ-Analyser quantifies neuromuscular junction morphology and innervation status in mouse models, identifying structural changes in ALS and peripheral neuropathy with high accuracy.

Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization

The paper shows that ALS/FTD risk variants in UNC13A increase sensitivity to TDP-43 depletion by promoting cryptic exon inclusion and protein loss.