Flora C. Y. Lee

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex development

This study identifies CDKL5 as a kinase that phosphorylates nELAVL proteins, enhancing mRNA binding and protein synthesis, and shows its role in visual cortex development.

HCR-Proxy resolves site-specific proximal RNA proteomes at subcompartmental nanoscale resolution

HCR-Proxy maps RNA-proximal proteomes at subcompartmental resolution, revealing sequence-encoded protein partitioning in nucleolar condensates.

Subcytoplasmic location of translation controls protein output

The paper shows that subcytoplasmic mRNA localization affects protein output by determining mRNA and protein abundance through compartment-specific translation environments.

Flow: a web platform and open database to analyse, store, curate and share bioinformatics data at scale

Flow provides a web platform and database for managing and analyzing large-scale bioinformatics data, addressing challenges in data processing, quality, and accessibility.

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion

This study identifies HNRNPH1 as a key regulator of RBM3 expression through cold-induced exon skipping, offering potential therapeutic targets for neuroprotection.

A computationally-enhanced hiCLIP atlas reveals Staufen1 RNA binding features and links 3' UTR structure to RNA metabolism

The paper extends a hiCLIP atlas of Staufen1-bound duplexes by 10-fold using computational methods and reveals structural features of RNA binding and their impact on RNA metabolism.

An improved iCLIP protocol

The paper introduces an improved CLIP protocol (iiCLIP) that produces more specific RNA binding site datasets compared to existing methods.

Common ALS/FTD risk variants in UNC13A exacerbate its cryptic splicing and loss upon TDP-43 mislocalization

The paper shows that ALS/FTD risk variants in UNC13A increase sensitivity to TDP-43 depletion by promoting cryptic exon inclusion and protein loss.

Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.