Adaptive Landscapes of Plasmodium Falciparum Dihydrofolate Reductase Reveal Pathways to Antifolate Resistance
Danny Muzata, Dwipanjan Sanyal, Deeptanshu Pandey, Soumyananda Chakraborti, Vladimir Nikolaevich Uversky, Prajna Upadhyay, Sourav Chowdhury
This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.
bioRxiv · Feb 2, 2026 · PreprintBiophysics