Danny Muzata

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.