Soumyananda Chakraborti

A Poly(rC)-Binding Protein Mediates Iron Delivery to Ferritin in Anopheles stephensi

This study identifies PCBP as a key mediator of iron delivery to ferritin in Anopheles stephensi, revealing its role in mosquito iron homeostasis and potential as a target for antimalarial strategies.

Pleiotropic antimalarial activities and immunomodulation exhibited by Himalayan Buransh (Rhododendron arboreum) in human and rodent malaria models

This study demonstrates the antimalarial and immunomodulatory effects of Himalayan Buransh in vitro, in vivo, and in silico, showing potential as an adjunct therapy for drug-resistant malaria.

Mosquito-directed PROTACs to block malaria transmission

This study evaluates a PROTAC molecule to degrade p38 MAPK in mosquitoes, disrupting Plasmodium falciparum development and enhancing immune gene expression, suggesting PROTACs as a novel strategy for malaria transmission control.

Adaptive Landscapes of Plasmodium Falciparum Dihydrofolate Reductase Reveal Pathways to Antifolate Resistance

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

Mosquito Ferritin: A Haem-Binding Iron Store Required for Egg Development and Targetable for Malaria Control

This study identifies mosquito ferritin as a critical iron-storage protein essential for egg development and highlights its potential as a target for malaria control through iron chelation.

Comparative study of manganese catalase monomers, interfaces and cage architecture within the ferritin superfamily

This study compares the structural features of manganese catalase with other ferritin subtypes, highlighting differences in monomer structure, interface arrangement, and cage architecture that support its catalytic function.

Navigating the Fitness Landscapes of Plasmodium falciparum Dihydrofolate Reductase: Evolutionary Insights into Antifolate Resistance

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

Functional disruption of Transferrin expression alters reproductive physiologyin Anopheles culicifacies

This paper characterizes a transferrin homolog in Anopheles culicifacies, showing its role in iron transport and reproductive physiology through expression analysis and RNAi experiments.