Deeptanshu Pandey

The paper identifies synergistic drug pairs in branched metabolic networks by analyzing topological complementarity in the E. coli folate pathway.

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.