Yannick D. Müller

This study designs PD-1-targeting CAR-T-cells to reduce the HIV reservoir by depleting specific T-cell subpopulations in HIV-infected humanized mice.

The paper analyzes lung-draining lymph nodes from COVID-19 autopsies to identify distinct follicular Bcl6 reactivity subgroups and their associated immune and spatial transcriptomic profiles.

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.