Spiros Georgakis

An eicosanoid-enriched follicular microenvironment shapes germinal centre immune dynamics in antiretroviral-treated PLWH

The paper identifies eicosanoid-enriched follicular microenvironments in HIV-infected individuals on antiretroviral therapy that may influence antibody responses and viral reservoir persistence.

Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cells

The paper identifies distinct follicular helper CD4 T cell programming in HIV-positive individuals who produce broadly neutralizing antibodies, linking it to improved B cell follicle architecture and reduced suppressor cells.

Targeting PD-1+ T-cells with Chimeric Antigen Receptors to reduce the HIV Reservoir

This study designs PD-1-targeting CAR-T-cells to reduce the HIV reservoir by depleting specific T-cell subpopulations in HIV-infected humanized mice.

Follicular Bcl6 reactivity is associated with a unique immune landscape and spatial transcriptome in COVID-19

The paper analyzes lung-draining lymph nodes from COVID-19 autopsies to identify distinct follicular Bcl6 reactivity subgroups and their associated immune and spatial transcriptomic profiles.

Redirecting TCR specificity in regulatory T cells toward class I HLA antigens mediates tissue-specific homing

The paper redirects TCR specificity in regulatory T cells toward class I HLA antigens to enhance tissue-specific homing in Type 1 Diabetes.