Human to yeast pathway transplantation: cross-species dissection of the adenine de novo pathway regulatory node
Neta Agmon, Jasmine Temple, Zuojian Tang, Tobias Schraink, Maayan Baron, Jun Chen, Paolo Mita, James A. Martin, Benjamin P. Tu, Itai Yanai, David Fenyö, Jef D. Boeke
The paper transplants the human adenine de novo pathway into yeast to study regulatory mechanisms, finding that PPAT/ADE4 is a central regulatory node influenced by metabolites and mutations.
Nucleic Acids Research · Nov 18, 2019Peer-reviewedSynthetic Biology