Martine Guillermier

Acetylcholine drives astrocytic JAK2-STAT3 signaling to modulate male-to-female approach behavior

The paper shows that acetylcholine activates astrocytic JAK2-STAT3 signaling in male mice, which is necessary for context-appropriate approach behavior toward estrus females.

Brain-specific PP1/LRRK2 interaction-targeting peptides as a novel strategy for Parkinson's disease treatment

The paper develops a peptide, PEP 3, that disrupts the LRRK2/PP1 interaction and shows promise as a therapeutic for Parkinson's disease by reducing dopaminergic cell death and alpha-synuclein phosphorylation.

AAV-mediated allele-specific silencing alleviates neuropathology in a novel non-human primate model of Spinocerebellar ataxia type 3

This study evaluates AAV9-miR-ATXN3 in a non-human primate model of SCA3, showing reduced neuropathology through allele-specific silencing of mutant ATXN3.

Reactive astrocytes promote proteostasis in Huntington disease through the JAK2-STAT3 pathway

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease

This study investigates the role of reactive astrocytes in Alzheimer's disease by modulating the JAK2-STAT3 pathway in 3xTg-AD mice, finding no effect on Tau or amyloid pathology but behavioral changes.