Author

Pauline Gipchtein

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Fanny PetitiD· 2 shared Martine Guillermier· 2 shared Alexis‐Pierre BemelmansiD· 1 shared Angelita RebolloiD· 1 shared Anne‐Sophie HérardiD· 1 shared Asma Touffeil Mohamed· 1 shared Cameron HéryiD· 1 shared Carole EscartiniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Fanny PetitORCID

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2 papers

Recent·Most cited

Brain-specific PP1/LRRK2 interaction-targeting peptides as a novel strategy for Parkinson's disease treatment

Séverine Loisel, Fanny Petit, Gwenaëlle Aurégan, Martine Guillermier, Marjorie Benfissa, Pauline Gipchtein, Asma Touffeil Mohamed, Kristina Põšnograjeva, Tambet Teesalu, Romina Aron Badin, Angelita Rebollo

The paper develops a peptide, PEP 3, that disrupts the LRRK2/PP1 interaction and shows promise as a therapeutic for Parkinson's disease by reducing dopaminergic cell death and alpha-synuclein phosphorylation.

bioRxiv · Jul 29, 2026 · PreprintNeuroscience

Reactive astrocytes promote proteostasis in Huntington disease through the JAK2-STAT3 pathway

Laurene Abjean, Lucile Ben Haim, Miriam Riquelme‐Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne‐Sophie Hérard, Marie‐Claude Gaillard, Martine Guillermier, Mylène Gaudin, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, , Carole Escartin

This study shows that activating the JAK2-STAT3 pathway in astrocytes reduces mutant Huntingtin aggregates and improves disease outcomes in Huntington's disease models.

Brain · Feb 17, 2022Peer-reviewedNeuroscience