Author

Mridula Annaswamy Srinivas

The University of Texas Southwestern Medical CenterORCID 0000-0002-9469-9136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Robert C. OrchardiD· 3 shared Linley R. Pierce· 2 shared Gail L. SturdevantiD· 1 shared Lawrence A. SchrieferiD· 1 shared Meagan E. SullenderiD· 1 shared Megan T. BaldridgeiD· 1 shared Mikayla C. Olson· 1 shared Rachel RodgersiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

Robert C. OrchardORCID

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3 papers

Recent·Most cited

A single amino acid mutation in norovirus NS4 promotes viral spread

Mridula Annaswamy Srinivas, Robert C. Orchard

This study identifies a single amino acid mutation in norovirus NS4 that rescues replication defects of a specialist virus, enabling it to spread more efficiently in vitro.

Journal of Virology · Apr 27, 2026Peer-reviewedMicrobiology

Trim47 inhibits murine norovirus replication in a strain-dependent manner

Stacey L. Crockett, Linley R. Pierce, Rachel Rodgers, Meagan E. Sullender, Lawrence A. Schriefer, Mridula Annaswamy Srinivas, Sanghyun Lee, Megan T. Baldridge, Robert C. Orchard

This study identifies Trim47 as a host restriction factor that inhibits murine norovirus strain CR6 but not strain CW3, revealing strain-specific antiviral mechanisms.

Journal of Virology · Nov 18, 2025Peer-reviewedMicrobiology

Trim7 does not have a role in the restriction of murine norovirus infection in vivo

Mridula Annaswamy Srinivas, Linley R. Pierce, Mikayla C. Olson, Shelly J. Roberston, Gail L. Sturdevant, Sonja M. Best, Robert C. Orchard

This study shows Trim7 does not restrict murine norovirus infection in vivo, despite its antiviral activity in cell culture.

Journal of Virology · Jun 4, 2025Peer-reviewedMicrobiology